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First up is a Champions League clash against PSV, but the real stakes come at the weekend — when Arsenal takes on Manchester City after the Reds have travelled to face Andoni Iraola's in-form Bournemouth side.
While Arne Slot certainly won't feel as though he could secure the title just yet, Arsenal might worry that it could throw it away.
Should Liverpool come through what is bound to be a tricky Bournemouth test, followed by dropped points for the Gunners, it would look like a long way back.
On the other hand, the worst-case scenario could still see Liverpool's lead at the top of the Premier League cut to just three points, with the potentially hazardous game in hand against Everton next up in the fixture list.
Having just demolished Nottingham Forest 5-0, Bournemouth is certainly not to be taken lightly.
After the win, Iraola conceded that his squad is "thin", and that was something of an understatement.
"We are taking the games game by game," Iraola told the BBC after the thumping Nottingham Forest win.
Bournemouth has gone 13 games without defeat, the third-longest unbeaten run in the Premier League, behind Liverpool and Arsenal
In its last two games, Bournemouth has dismantled Newcastle's own unbeaten run, and blitzed high-flying Forest
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