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The Dutchman also all but ruled out Conor Bradley, who was forced off after 89 minutes in the draw with Aston Villa.
Slot said in his Thursday press conference: "No, he [Bradley] still has to come in, so we don't know yet.
"Joe Gomez had surgery for his hamstring injury, so he's out for a long time.
He will be back maybe just before the end of the season.
"Then, of course, these two players are not injured but they come back from an injury – [Diogo] Jota and Trent [Alexander-Arnold], so that's also the reason they don't play 90 minutes five times in a row in 15 days.
The Netherlands international has missed Liverpool's last two Premier League matches and has yet to return to team training.
.
It will be a close call."
Liverpool's injury issues will ensure that Slot is cautious over his team selections in the coming weeks.
The disrupted season of Diogo Jota sees the Dutchman taking a restrained approach as he continues to return from injury despite providing an assist in his last outing.
"I would have loved to have played him every single time for maybe 90 minutes," said Slot, "But if a player is out for four or five months and he hasn't been out out, he has been coming back, coming in, coming back and every time we played him a bit too much he got injured again, I hope people understand why we are so cautious now.