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Changes may need to be made ahead of a midweek round of top-flight fixtures, with the Fantasy Premier League (FPL) deadline falling at 6pm (GMT) on Tuesday February 25.
All 20 Prem sides will be in action across Tuesday, Wednesday and Thursday night, with Tottenham Hotspur vs Manchester City, Nottingham Forest vs Arsenal and Liverpool vs Newcastle United the standout fixtures.
Several FPL heavyweights are at risk of missing out, so here, Express Sport takes you through the latest injury news on six popular picks...
Erling Haaland
Pep Guardiola is hopeful that the City striker will return in time for the trip to Spurs on Wednesday.
Manager Unai Emery subsequently admitted it was only because of a kick, and he hopes Rogers will be ready to return against Crystal Palace on Tuesday.
Emile Smith Rowe
The former Arsenal man hobbled off during Fulham's defeat at home to Palace on Saturday.
"It is difficult to say if he's going to be ready," said Silva.
Danny Welbeck
The Brighton veteran missed Saturday's big win at Southampton, and Seagulls manager Fabian Hurzeler admits he will be careful about risking him at home to Bournemouth next time out.
We won't take any risks."
Dominic Solanke
Tottenham's starting striker has been sidelined with a knee issue since mid-January.
He was given a six-week recovery prognosis just about six weeks ago, but the Europa League clash with AZ Alkmaar on March 6 is currently deemed his most-likely return date, and he is expected to sit out the City showdown.
Sven Botman
The Dutch defender has missed Newcastle's last three games with a knee problem, and further assessments will take place ahead of Wednesday's trip to Anfield.
"He is making good progress," said Magpies manager Eddie Howe.
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