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The defending champion though still has plenty of firepower at its disposal - even if Erling Haaland is out.
Here, Liverpool.com has picked out all of the information that you need to know, including the kick-off time, TV details, highlights and early team news.
Yes, fans in the UK will be able to watch the game live.
It will be broadcast on Sky Sports Main Event and Sky Sports Premier League, with coverage beginning straight after Newcastle's clash with Nottingham Forest at 2pm.
Fans in the US will also be able to watch live.
The game will be available on TV and for streaming on Peacock.
Want to watch more live sports?
Peacock offers plans starting at $7.99 so you can stream live sports like NFL, Premier League, and Big Ten Football.
Where can I catch the highlights?
The goals will also be shared online alongside key moments in the match.
You can follow all the updates and read the analysis on Liverpool.com and you can also follow along live on our social channels including on X and Facebook, and catch the post-match press conferences on the Blood Red YouTube channel.
Early team news
Liverpool will have to make a late decision on Cody Gakpo, with the forward facing a race against time to be fit for today's game.
For more news relating to Newcastle United, visit our sister site NUFC Latest Live.