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Arsenal, Aston Villa and Liverpool all finished in the top eight of this year's new look competition to avoid the play-off round, which included the likes of Bayern Munich, Celtic and Manchester City.
All three teams were given four potential opponents at the end of the group phase.
And with the first round of play-off fixtures now done and dusted, that figure has now dropped to three.
Here, Mirror Football rounds up the state of play ahead of Wednesday night's matches, which will see the picture become even clearer...
Permutations for top eight
LIVERPOOL AND BARCELONA: Will play one of Brest, PSG or Benfica.
ARSENAL AND INTER: Will play one of PSV, Feyenoord or Juventus.
ATLETICO MADRID AND BAYER LEVERKUSEN: Will play one of Real Madrid, Bayern Munich or Manchester City.
LILLE AND ASTON VILLA: Will play one of Borussia Dortmund, Sporting Lisbon or Club Brugge.
There will be more to follow on this breaking news storyand Mirror Sport will bring you the very latest updates, pictures and video as soon as possible.
Please check back regularly for updates on this developing story.
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