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One interesting storyline is the possible debut of young right-back Isaac Mabaya.
Liverpool’s lineup will also depend on who needs rest.
Virgil van Dijk and Ibrahima Konate may get a break.
That could mean a rare start for Wataru Endo in central defense.
In midfield, Tyler Morton is pushing for more game time.
Federico Chiesa, who has been slowly building his minutes, may also get another chance.
Liverpool Predicted team vs Plymouth
Slot is likely to go with a similar team to the one that beat Accrington Stanley in the previous round.
That means Caoimhin Kelleher could start in goal.
In defense, Conor Bradley might keep his place, with Jarell Quansah partnering Endo at center-back.
In midfield, Alexis Mac Allister could play alongside Morton and Curtis Jones.
Up front, Harvey Elliott and Darwin Nunez are expected to start, with Chiesa completing the attack.
The predicted lineup is:
Kelleher, Bradley, Quansah, Endo, Tsimikas, Mac Allister, Morton, Jones, Elliott, Nunez, Chiesa.
With no major injuries or suspensions, this lineup gives Liverpool a solid balance of experience and rotation.
The Reds will be expected to get the job done, but Plymouth won’t make it easy.
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