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The draw with Villa resulted in Conor Bradley being substituted due to a muscle injury with 24 minutes remaining.
Liverpool is still awaiting full details on the right-back's condition, but he is anticipated to miss both the City trip and Wednesday's match against Newcastle.
Bradley joins Joe Gomez, Cody Gakpo, and Tyler Morton in the Reds' treatment room.
Gomez has had surgery on a hamstring injury and isn't expected to return until the season's final weeks.
Conor Bradley was forced off with an injury late on vs Aston Villa.
Adding to Liverpool's injury woes, Morton has had surgery on a shoulder problem, sidelining him for the foreseeable future.
This latest blow leaves Slot without a natural substitute for Trent Alexander-Arnold, who, along with Diogo Jota, is just coming back from an injury himself
He is improving.
"These two players are not injured but they come back from an injury – [Diogo] Jota and Trent [Alexander-Arnold], so that's also the reason they don't play 90 minutes five times in a row in 15 days
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