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Liverpool's perfect run in this Champions League campaign came to an end with a 3-2 defeat at PSV - but Barcelona's draw at home to Atalanta meant Arne Slot's side finished the league phase in top spot.
With twists and turns further down the table on Wednesday, Liverpool will face either PSG, Benfica, Monaco or Brest in the last 16, once those sides have gone through the play-offs.
Few will want to play Liverpool on the basis of their league-phase performances - although nine changes for this final fixture, including nights off for Mohamed Salah, Alisson, Virgil van Dijk, Trent Alexander-Arnold and more regulars, gave their Dutch hosts a helping hand.
PSV capitalised and can look forward to a play-off against either Feyenoord or Juventus for a last-16 spot of their own.
Cody Gakpo, back playing against his former club, dispatched an early penalty after Federico Chiesa was brought down, and Harvey Elliott looked to have Liverpool in control heading into the break when he put away the follow-up to a saved Chiesa shot, after Johan Bakayoko's fine equaliser.
But Ismael Saibari smashed in from a tight angle and Ricardo Pepi converted from close-range to flip the match around.
Team news: Nine changes for Liverpool
Mo Salah, Trent Alexander-Arnold, Virgil van Dijk, Alisson Becker, Ibrahima Konate, Ryan Gravenberch, Alexis Mac Allister, Dominik Szoboszlai, Luis Diaz, Joe Gomez, Curtis Jones and Diogo Jota were all left out of Liverpool's squad.
Youngsters Jayden Danns and James McConnell were handed starts, alongside former PSV player Cody Gakpo.
The second half was far less thrilling, with the back and forth in Barcelona drawing attention and switching Liverpool from first to second and up again in the live table.
Tyler Morton produced a super tackle to deny Saibari and gave Liverpool hope of preserving an unbeaten record but when 18-year-old Amara Nallo was sent off just four minutes into his senior debut for a last-man foul on Bakayoko the result was sealed.
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That won't worry Slot, though.
It's mission complete for his Liverpool team in this phase of the competition.
Their fight on four fronts continues, with attention switching to Saturday's tricky 3pm Premier League trip to Bournemouth while they await their Champions League knockout opponents and pathway to be revealed in the upcoming draws.
More to follow...
When are the knock-out draws?
To determine who plays who in the knockout rounds, there will be two draws after the league phase.
The first draw on Friday January 31 at 11am will determine which of the two options each team will get in the knockout playoff.
For example, a team finishing 13th will find out whether they are playing against the team finishing 19th or 20th.
Seeded teams (9th-16th) will have the second leg at home and those play-off round matches take place on February 11/12 and February 18/19.
Teams seeded from 1st to 8th will have to wait until Friday February 21 to find out their opponents.
That draw will then determine who they face in the round of 16, and ultimately map out their full path to the final.
When are the 2024/25 Champions League knockout fixtures?Round of 16: March 4/5 and March 11/12, 2025Quarter-finals: April 8/9 and April 15/16, 2025Semi-finals: April 29/30 and May 6/7, 2025Final: May 31, 2025What's coming up for Liverpool?