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Meanwhile, Villa, currently ninth in the table, is keen to keep its European aspirations alive for the 2025/26 season, just five points shy of Europa League qualification and six from the Champions League.
Unai Emery's squad has made a strong impression on the European stage throughout 2024/25, finishing eighth in the new league format with five victories, one draw and just two defeats from eight games.
The Villains are next in line to face either Club Brugge, Borussia Dortmund or Sporting CP in the Round of 16, as they aim for their first Champions League title since their 1-0 triumph over Bayern Munich in 1982.
Speaking ahead of the game, Slot said: "I think Villa away, when you get the fixture list, you all know that Villa away is one of the tougher ones you can face.
"So, [a] very good manager, always has a very good game plan
Villa brought in quite a lot of good players in the winter break as well and already had a very good team
Villa qualified for [the] top eight in the Champions League, so it tells you that it's a strong team we are going to face
"But that's what I started with, Wolves at home was also tough for us, so every game in this period of time for every team in the league is difficult."