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He joins Joe Gomez and Tyler Morton on the sidelines after both underwent surgery on respective injuries earlier this month.
Elsewhere, Slot confirmed on Tuesday that Alexis Mac Allister will be available to face Newcastle after being spotted with a black eye in the wake of the win at the Etihad.
But there was no update on whether Cody Gakpo and Diogo Jota are available to start for the league leaders.
The former suffered an ankle injury in the 2-2 draw against Everton two weeks ago and missed the Wolverhampton Wanderers and Villa games but returned to training at the weekend and came off the bench in the latter stages against City.
Diogo Jota was an unused substitute against Manchester City
As for Jota, Slot said on Sunday : “Diogo Jota told me yesterday that he wasn’t fully recovered yet, so he couldn’t start.”
It comes after the Portugal international started back-to-back games against Wolves and Villa
Prior to the Wolves match, the 28-year-old hadn’t started a league match in nearly four months.
As for Newcastle, it is without Jamaal Lascelles, but Sven Botman and Joelinton could return.
“Sven's improving and he's improving quickly, so we'll see whether he makes the game or not,” Eddie Howe said ahead of the game
Again with Joe, similar to Sven, really improving, doing really well, pushing and again he's another player that will be quite close.”
Sandro Tonali is also available to start again after beginning the 4-3 win over Nottingham Forest on Sunday on the bench.
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