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On paper, this should be Liverpool's easiest game of the Premier League season.
The title is virtually secured after all and Saints are in the running to be one of the worst Premier League teams in history.
Ryan Gravenberch can stay in the double pivot with Wataru Endo coming in, and Curtis Jones as the number 10.
Up top, Darwin Nunez can lead the line, with Mohamed Salah on the right and Luis Diaz on the left.
My team (4-2-3-1): Alisson; Alexander-Arnold, Quansah, Van Dijk, Tsimikas; Gravenberch, Endo; Salah, Jones, Diaz; Nunez
Paul Gorst
Sixteen points clear sounds like the quite the incentive for today but I think there might be some resting and rotating ahead of a major week of Champions League and Carabao Cup final action.
Arne Slot has rarely shuffled his pack too firmly during his time on Merseyside but if the Reds boss can’t trust some of his fringe players against the division’s worst side in Southampton then something really is amiss.
I am not going to go too ‘Plymouth away in the Cup’ here but Harvey Elliott and Curtis Jones have certainly staked their respective claims and there’s a nod for Darwin Nunez too, who can build on an encouraging cameo in Paris on Wednesday night.
I did think about starting Jarell Quansah at right-back also but Trent Alexander-Arnold keeps his place
This feels like a good one for Kostas Tsimikas too.
My team (4-2-3-1): Alisson; Alexander-Arnold, Konate, Van Dijk, Tsimikas; Gravenberch, Jones; Salah, Elliott, Diaz; Nunez
Theo Squires
Liverpool could move 16 points clear at the top of the Premier League table if they beat Southampton on Saturday
It is an opportunity they really cannot afford to squander against the strugglers.
Coming fast off the back of the midweek trip to Paris, and with PSG looming again on Tuesday, I’m making a few changes for this one.
Kostas Tsimikas can come in at left-back, while Wataru Endo is handed a long-awaited first Premier League start of the season as Ryan Gravenberch is rested
I am tempted to give Harvey Elliott a start too, but in all honesty, I just can’t see Arne Slot turning to him despite his PSG heroics.
Darwin Nunez does get the chance to lead the line though, after setting up Elliott’s winner, with Luis Diaz and Diogo Jota both dropping to the bench.
My team (4-2-3-1): Alisson; Alexander-Arnold, Konate, Van Dijk, Tsimikas; Endo, Mac Allister; Salah, Szoboszlai, Jones; Nunez