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Kostas Tsimikas is named on the left.
In midfield, Wataru Endo and James MCConnell can patrol and I am going to name Harvey Elliott in the No.10 position to pull the strings.
My front three sees Diogo Jota start through the middle for just the second time since October while Federico Chiesa gets another start in lieu of Mohamed Salah, who can rest up back on Merseyside.
Rio Ngumoha gets the nod on the left-hand side with Darwin Nunez waiting in the wings.
My team (4-2-3-1): Kelleher; Bradley, Gomez, Quansah, Tsimikas; Endo, McConnell; Chiesa, Elliott, Ngumoha; Jota.
The FA Cup remains the world's greatest domestic club knockout competition.
The rest of the defence, though, is rotated with Jarell Quansah and Joe Gomez coming in at centre-back and Kostas Tsimikas at left-back.
It's all change in midfield, with Wataru Endo and James McConnell at the base of the engine room and Harvey Elliott operating as the number 10.
And up top, Federico Chiesa can have another go on the right, with Diogo Jota down the middle and Luis Diaz on the opposite flank.
Alexis Mac Allister can be the first substitute.
My team (4-2-3-1): Kelleher; Bradley, Quansah, Gomez, Tsimikas; Endo, McConnell; Chiesa, Elliott, Diaz; Jota.
Don't be kidded by all the cliches, the FA Cup remains the least of Liverpool's priorities this season.
With one Wembley final already in the bag, the Champions League now entering the business end of the competition and a Premier League title to be won, Liverpool have to manage their resources carefully.
That being said, no team should ever turn their nose up at silverware, and Liverpool will be able to put out a side that can overcome the Championship's bottom club, Plymouth.
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Caoimhin Kelleher will start his second consecutive match in goal, with Conor Bradley, Jarell Quansah, Joe Gomez and Kostas Tsimikas the back four.
In midfield, Wataru Endo can be joined by James McConnell and Harvey Elliott, and then it's Federico Chiesa and Luis Diaz either side of Diogo Jota.
The latter two, though, can have their minutes managed rather carefully to ensure they don't pick up any unwanted knocks.
My team (4-2-3-1): Kelleher; Bradley, Quansah, Gomez, Tsimikas; Endo, McConnell; Chiesa, Elliott, Diaz; Jota.