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That means a striker drops out and with Cody Gakpo somewhat of a doubt, I think Luis Diaz and Mohamed Salah will lead the line as wide forwards and Curtis Jones and Dominik Szoboszlai will be encouraged to infiltrate central areas from deep.
Diogo Jota and Darwin Nunez can wait in the wings.
Andy Robertson keeps his place at left-back for this one and no Conor Bradley means Trent Alexander-Arnold definitely starts.
My team (4-4-2): Alisson; Alexander-Arnold, Konate, Van Dijk, Robertson; Gravenberch, Mac Allister, Jones, Szoboszlai; Salah, Diaz
Ian Doyle
The Champions League round of 16 is among us, and the reward for Liverpool finishing top of the first stage is to play arguably the most in-form team in Europe at present.
May as well have finished eighth.
And that means Alisson Becker in goal, Ibrahima Konate and skipper Virgil van Dijk at centre-back, Andy Robertson left-back and Trent Alexander-Arnold right-back.
Slot should stick to his usual midfield.
So it's Ryan Gravenberch and Alexis Mac Allister as the double pivot and Dominik Szoboszlai as the number 10.
None of the false nine stuff this evening for me, and with Cody Gakpo not quite ready, Luis Diaz is on the left of the attack, Mohamed Salah on the right and Diogo Jota down the middle.
My team (4-2-3-1): Alisson; Alexander-Arnold, Konate, Van Dijk, Robertson; Gravenberch, Mac Allister; Salah, Szoboszlai, Diaz; Jota
Theo Squires
Arne Slot shouldn't have too many difficult decisions to make for Wednesday's clash with PSG.
In midfield, Curtis Jones remains limited to bench duty as Ryan Gravenberch and Alexis Mac Allister sit deep with Dominik Szoboszlai ahead of them
It's much important Liverpool have him fit and firing for the run-in than risking him in Paris if not 100% fit.
My team (4-2-3-1): Alisson; Alexander-Arnold, Konate, Van Dijk, Robertson; Gravenberch, Mac Allister; Salah, Szoboszlai, Diaz; Jota