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Former Liverpool striker Dominic Solanke put Spurs in front early on but Luis Diaz drew the hosts level a mere four minutes later after a VAR review.
Alexis Mac Allister then thundered a world-class strike into the top corner to make Anfield explode before Cody Gakpo made it 3-1 on just 34 minutes.
Arne Slot's champions were comfortably superior throughout and poured the pain on the Londoners in the second half with Mohamed Salah making it four before a Destiny Udogie own goal completed the rout.
Had a couple of shots well blocked but it was his cross that Udogie turned into his own net for the fifth.
Ibrahima Konate - 7
Conceded the corner for Spurs' goal but produced a vital touch to stop Mathys Tel making it 3-2 before half-time and didn't have much too do defensively after that.
Virgil van Dijk - 7
Great block to get in front of a goal-bound Tel shot and found himself busy up against Solanke.
As deserving as any Liverpool player of Premier League champion status.
Dominik Szoboszlai - 8
One of his better performances for a while as he matched his energy off the ball with more quality on it.
Finally got his goal, his 28th Premier League strike of this title-winning season, on the hour mark by cutting inside and blasting inside the near post.
Denied a second goal by a Udogie touch which went into his own net.
Luis Diaz - 8
Lost Dominic Solanke for the Spurs opener but then made amends on his 100th Premier League appearance with the leveller.
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