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The Reds said his Dutch compatriot picked up a minor knock in the Merseyside derby.
Alisson Becker remains in goal with Trent Alexander-Arnold coming in at full-back ahead of Conor Bradley.
Ibrahima Konate and Virgil van Dijk are at center-back with Andy Robertson at left-back.
Kostas Tsimikas is on the bench.
In midfield, Liverpool goes with Ryan Gravenberch, Alexis Mac Allister and Dominik Szoboszlai again.
Gakpo is absent, Darwin Nunez is among the subs, and Federico Chiesa comes back into the matchday squad.
"On the pitch, our aim on Sunday is simple," Van Dijk writes in his matchday program notes.
"We want to win every game we play, whether at Anfield or elsewhere, and we hope we can show the best of ourselves against Wolverhampton Wanderers.
We are in a very good position and there are a lot of games to play in the upcoming weeks."
Liverpool starting XI: Alisson; Alexander-Arnold, Konate, Van Dijk, Robertson; Szoboszlai, Gravenberch, Mac Allister; Salah, Jota, Diaz