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From situations with Mohamed Salah and Trent Alexander-Arnold to developlments away from Anfield, three things could threaten to bring about a nightmare end to the season.
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And if Salah were to pick up a problem, it would test Slot's problem-solving skills to their limit.
Trent Alexander-Arnold distracted by Real Madrid talks
Even while everything is still rosy for Liverpool on the pitch, there is something of a dark cloud gathering.
But the brutal reality is that more or less any supporter would reluctantly trade away all three of them if it meant guaranteeing this season's title.
In a sense, Liverpool made a decision along those lines in January, refusing to even entertain interest from Real Madrid in a January deal for Alexander-Arnold.
He has not been at his glittering best by any means, but he at least picked himself up after a horror show against Manchester United.
But if Alexander-Arnold takes his eye off the ball between now and the end of the campaign, perhaps with Real Madrid talks ramping up, then it could spell trouble
As Slot pointed out recently, it's a mark of how well his own team has done that it has not ceded any ground at all across the course of Mikel Arteta's 15-game sequence without defeat.
But if Arsenal irons out those draws and starts stacking up win after win, Liverpool will face even more strain
Whether Liverpool has what it takes to go above and beyond that tally is unclear, especially with Slot coaching a team still more or less identical to the one that ran out of steam under Jurgen Klopp last season.
Of course, the chances of a perfect Arsenal run are low, especially with attacking injury issues mounting up
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