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Plymouth's reward for beating Liverpool in the FA Cup is a fifth round tie away to Manchester City.
The Pilgrims dumped the current Premier League leaders out of the competition with a 1-0 win on Sunday thanks to Ryan Hardie’s second-half penalty, and will now head to the Etihad Stadium for a last-16 tie against the seven-time Cup winners, who had to come from behind to beat Leyton Orient 2-1 on Saturday.
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There was no VAR in operation during the fourth-round ties over the weekend, but the technology will come into play from the next round onwards.
Brighton, who came from behind to beat Chelsea 2-1, also have another tough assignment as they are away to Carabao Cup finalists Newcastle.
Elsewhere, holders Celtic will host 2016 winners Hibernian, who are unbeaten in their last 11 matches.
In-form city rivals Hearts, who progressed to the last eight with a penalty shootout victory away to St Mirren on Monday, will host top-flight rivals Dundee, whom they thrashed 6-0 earlier this month
Championship promotion chasers Livingston will host 2021 winners and Premiership strugglers St Johnstone.
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