The Arsenal defender felled Mohamed Kudus and despite an initial yellow card being shown, VAR reviewed the incident and advised a red be shown.
A statement read: "VAR checked the referee’s call of yellow card to Lewis-Skelly for a challenge on Kudus – deeming it denial of an obvious goal-scoring opportunity due to the goalkeeper’s position and there being no covering defender, therefore recommended an on-field review.
The Reds welcome Newcastle to Anfield while Arsenal has a tricky trip to Nottingham Forest.
Speaking ahead of Sunday's encounter, Arne Slot said: "What I always expect from City since Pep is there: a great football team that can play so well.
City has had maybe one or two months in the seven or eight years he's there now that weren't the best, maybe partly because of injuries as well
So what you expect is what everybody expects if you go to the Etihad if you play against City
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